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Aurintricarboxylic acid

CAS No. 4431-00-9

Aurintricarboxylic acid( ATA | NSC-4056 | NSC 4056 | NSC4056 )

Catalog No. M24401 CAS No. 4431-00-9

Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Aurintricarboxylic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases.
  • Description
    Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
  • In Vitro
    Western Blot Analysis Cell Line:T98G, A172, GBM44 glioma cells Concentration:10 μM Incubation Time:0.5 hour, 1 hour, 2 hours Result:Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines.
  • In Vivo
    ——
  • Synonyms
    ATA | NSC-4056 | NSC 4056 | NSC4056
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|MicroRNA|rP2X1|rP2X3|Topoisomerase II
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4431-00-9
  • Formula Weight
    422.35
  • Molecular Formula
    C22H14O9
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (295.97 mM; Need ultrasonic)
  • SMILES
    OC(c(cc(cc1)C(c(cc2)cc(C(O)=O)c2O)=C(C=C2)C=C(C(O)=O)C2=O)c1O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liu T T , Yang T , Gao M N , et al. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations[J]. Acta Pharmacologica Sinica, 2019.
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